全文获取类型
收费全文 | 5368篇 |
免费 | 521篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 210篇 |
妇产科学 | 121篇 |
基础医学 | 757篇 |
口腔科学 | 71篇 |
临床医学 | 617篇 |
内科学 | 1107篇 |
皮肤病学 | 38篇 |
神经病学 | 569篇 |
特种医学 | 154篇 |
外科学 | 768篇 |
综合类 | 82篇 |
一般理论 | 1篇 |
预防医学 | 514篇 |
眼科学 | 364篇 |
药学 | 342篇 |
中国医学 | 1篇 |
肿瘤学 | 165篇 |
出版年
2021年 | 56篇 |
2020年 | 42篇 |
2019年 | 82篇 |
2018年 | 82篇 |
2017年 | 60篇 |
2016年 | 63篇 |
2015年 | 84篇 |
2014年 | 118篇 |
2013年 | 195篇 |
2012年 | 282篇 |
2011年 | 304篇 |
2010年 | 165篇 |
2009年 | 156篇 |
2008年 | 281篇 |
2007年 | 325篇 |
2006年 | 310篇 |
2005年 | 334篇 |
2004年 | 314篇 |
2003年 | 320篇 |
2002年 | 266篇 |
2001年 | 137篇 |
2000年 | 126篇 |
1999年 | 116篇 |
1998年 | 72篇 |
1997年 | 54篇 |
1996年 | 41篇 |
1995年 | 58篇 |
1994年 | 49篇 |
1993年 | 42篇 |
1992年 | 88篇 |
1991年 | 85篇 |
1990年 | 64篇 |
1989年 | 76篇 |
1988年 | 86篇 |
1987年 | 86篇 |
1986年 | 60篇 |
1985年 | 82篇 |
1984年 | 38篇 |
1983年 | 44篇 |
1982年 | 30篇 |
1980年 | 29篇 |
1979年 | 42篇 |
1978年 | 49篇 |
1977年 | 42篇 |
1976年 | 31篇 |
1975年 | 40篇 |
1974年 | 40篇 |
1973年 | 38篇 |
1972年 | 35篇 |
1971年 | 31篇 |
排序方式: 共有5898条查询结果,搜索用时 171 毫秒
1.
Raymond J. Chan RN PhD Vivienne E. Milch MBBS MHPol Fiona Crawford-Williams PhD Oluwaseyifunmi Andi Agbejule BRadTherapy Ria Joseph MNutrDiet Jolyn Johal BND Narayanee Dick BSc Matthew P. Wallen PhD Julie Ratcliffe PhD Anupriya Agarwal MBBS Larissa Nekhlyudov MD Matthew Tieu PhD Manaf Al-Momani BPharm Scott Turnbull PhD Rahul Sathiaraj MPH Dorothy Keefe MBBS MD Nicolas H. Hart PhD 《CA: a cancer journal for clinicians》2023,73(6):565-589
Patient navigation is a strategy for overcoming barriers to reduce disparities and to improve access and outcomes. The aim of this umbrella review was to identify, critically appraise, synthesize, and present the best available evidence to inform policy and planning regarding patient navigation across the cancer continuum. Systematic reviews examining navigation in cancer care were identified in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Cumulative Index of Nursing and Allied Health (CINAHL), Epistemonikos, and Prospective Register of Systematic Reviews (PROSPERO) databases and in the gray literature from January 1, 2012, to April 19, 2022. Data were screened, extracted, and appraised independently by two authors. The JBI Critical Appraisal Checklist for Systematic Review and Research Syntheses was used for quality appraisal. Emerging literature up to May 25, 2022, was also explored to capture primary research published beyond the coverage of included systematic reviews. Of the 2062 unique records identified, 61 systematic reviews were included. Fifty-four reviews were quantitative or mixed-methods reviews, reporting on the effectiveness of cancer patient navigation, including 12 reviews reporting costs or cost-effectiveness outcomes. Seven qualitative reviews explored navigation needs, barriers, and experiences. In addition, 53 primary studies published since 2021 were included. Patient navigation is effective in improving participation in cancer screening and reducing the time from screening to diagnosis and from diagnosis to treatment initiation. Emerging evidence suggests that patient navigation improves quality of life and patient satisfaction with care in the survivorship phase and reduces hospital readmission in the active treatment and survivorship care phases. Palliative care data were extremely limited. Economic evaluations from the United States suggest the potential cost-effectiveness of navigation in screening programs. 相似文献
2.
3.
4.
Megumi Oshima Brendon L. Neuen JingWei Li Vlado Perkovic David M. Charytan Dick de Zeeuw Robert Edwards Tom Greene Adeera Levin Kenneth W. Mahaffey Luca De Nicola Carol Pollock Norman Rosenthal David C. Wheeler Meg J. Jardine Hiddo J.L. Heerspink 《Journal of the American Society of Nephrology : JASN》2020,31(12):2925
5.
6.
Megumi Oshima Meg J. Jardine Rajiv Agarwal George Bakris Christopher P. Cannon David M. Charytan Dick de Zeeuw Robert Edwards Tom Greene Adeera Levin Soo Kun Lim Kenneth W. Mahaffey Bruce Neal Carol Pollock Norman Rosenthal David C. Wheeler Hong Zhang Bernard Zinman Hiddo J.L. Heerspink 《Kidney international》2021,99(4):999-1009
7.
8.
Paediatric critical incident analysis: lessons learnt on analysis,recommendations and implementation
Cynthia van der Starre Monique van Dijk Ada van den Bos Dick Tibboel 《European journal of pediatrics》2014,173(11):1449-1457
The objectives of this study were to identify causal and contributing factors of serious patient safety incidents in a paediatric university hospital, to report on ensuing recommendations and to assess the extent of implementation of the recommendations. The possible causal and contributing factors identified in 17 incidents were classified by a system devised by Vincent et al. Proposed recommendations were classified by the same system, and degrees of implementation were established. A median of 5 causal and contributing factors per incident were identified. Twenty-two percent of all factors were related to teamwork and 22 % to task factors. A median of 5 recommendations per analysis were formulated. Most recommendations were related to task factors (36 %). The time load of each analysis was a mean of 27 h. One third of the recommendations have been acted upon, mostly those related to task and team factors. Conclusion: Incident analysis is time-consuming but yields indispensable information on causal and contributing factors, presenting numerous opportunities for quality improvement. The value of these analyses could be improved by appointing responsibilities and setting up time frames for implementation. A bottom-up approach with managerial support appears to be a key to turning incident analysis and quality improvement into an ongoing process. 相似文献
9.
Nguyen Thoa C Witter Dick J Bronkhorst Ewald M Truong Nhan B Creugers Nico HJ 《BMC oral health》2010,10(1):1-11
Background
Dental caries is one of the primary causes of tooth loss among adults. It is estimated to affect a majority of Americans aged 55 and older, with a disproportionately higher burden in disadvantaged populations. Although a number of treatments are currently in use for caries prevention in adults, evidence for their efficacy and effectiveness is limited.Methods/Design
The Prevention of Adult Caries Study (PACS) is a multicenter, placebo-controlled, double-blind, randomized clinical trial of the efficacy of a chlorhexidine (10% w/v) dental coating in preventing adult caries. Participants (n = 983) were recruited from four different dental delivery systems serving four diverse communities, including one American Indian population, and were randomized to receive either chlorhexidine or a placebo treatment. The primary outcome is the net caries increment (including non-cavitated lesions) from baseline to 13 months of follow-up. A cost-effectiveness analysis also will be considered.Discussion
This new dental treatment, if efficacious and approved for use by the Food and Drug Administration (FDA), would become a new in-office, anti-microbial agent for the prevention of adult caries in the United States.Trial Registration Number
NCT00357877 相似文献10.
XinRui Qi Sabina Luchetti Ronald W. H. Verwer Arja A. Sluiter Matthew R. J. Mason JiangNing Zhou Dick F. Swaab 《Brain pathology (Zurich, Switzerland)》2018,28(4):536-547
Altered levels of steroids have been reported in the brain, cerebral spinal fluid and plasma of patients with mood disorders. Neuroimaging studies have reported both functional and structural alterations in mood disorders, for instance in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). In order to determine whether the endogenous production of steroids is altered in the ACC and DLPFC of patients with major depressive disorder (MDD) or bipolar disorder (BPD), quantitative real‐time PCR was performed to detect mRNA expression level of key enzymes in the steroid biosynthetic pathways. In MDD, a significant decrease in mRNA level of cytochrome P450 17A1 (CYP17A1, synthesizing C19 ketosteroids) in the ACC and a significant increase in mRNA levels of hydroxysteroid sulfotransferase 2A1 [SULT2A1, catalyzing the sulfate conjugation of dehydroepiandrosterone (DHEA)] were observed in the DLPFC, suggesting alterations in DHEA and its sulfate metabolite DHEAS levels. Decreased intensity and distribution of CYP17A1 immunohistochemical staining was found in the ACC of MDD patients. Interestingly, there was a significant positive correlation between the mRNA levels of CYP17A1 and tyrosine‐related kinase B (TrkB) full length isoform. In a unique post‐mortem human brain slice culture paradigm, BDNF mRNA expression was found to be significantly increased following incubation with DHEA. Together, these data indicate a close relationship between DHEA and BDNF‐TrkB pathways in depression. Furthermore, in the DLPFC, higher mRNA levels of 11β‐hydroxysteroid dehydrogenase‐1 (HSD11B1, reducing cortisone to the active hormone cortisol) and steroidogenic acute regulatory protein (STAR, facilitating the shuttle of cholesterol through the intermembrane space) were found in the MDD patients and BPD patients, respectively. In conclusion, this study suggests the presence of a disturbance in the endogenous synthesis of DHEA and DHEAS in mood disorders, which has a close relationship with BDNF‐TrkB signaling. 相似文献